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Nov 3, 2021 · PAD2 can also citrullinate certain transcription factors to mediate the differentiation of immune cells. The knockout of Pad2 gene in mice can cause a shift in maturation of Th cells, which increases the differentiation of Th2 cells but decreases the differentiation of Th17 cells, rendering the mice susceptible to allergic airway inflammation .
Jun 6, 2022 · PAD2 is normally expressed in a variety of tissues in the body, with the brain being among the highest PAD2-expressing tissues . PAD2 plays important physiological roles in several cellular processes , and is known to be expressed by oligodendrocytes where it regulates gene transcription and citrullination of myelin basic protein (MBP) (6, 7).
- 10.3389/fneur.2022.874211
- 2022
- Front Neurol. 2022; 13: 874211.
Apr 27, 2020 · Of the five PAD enzymes, PAD2 and PAD4 are most strongly implicated in the pathogenesis of RA 7,8,9,10,11.Importantly, PAD2 and PAD4 are the only PAD enzymes expressed in immune cells; PAD2 is ...
- Ashley M. Curran, Pooja Naik, Jon T. Giles, Erika Darrah
- 2020
Sep 1, 2023 · PAD2 has been found to be significantly expressed in a variety of malignant tumors, including gastric cancer, liver cancer, colorectal cancer, esophageal cancer, breast cancer, and skin tumors. It is considered a pathogenic factor in cancer and a potential tumor marker [ 23 ]. There are many factors contributing to the high expression of PAD2 ...
Nov 18, 2022 · Protein arginine deiminase (PAD) expression in macrophages polarized to proinflammatory (M1) and anti-inflammatory (M2) phenotypes. PAD1, PAD2 and PAD4 expression was upregulated in M1 macrophages, while PAD2 was strongly downregulated in M2 macrophages. mRNA expression of PAD1, PAD2 and PAD4 in THP-1 macrophages treated with LPS (M1 phenotype) or IL-4 (M2 phenotype) for 48 h. mRNA expression ...
Aug 30, 2023 · Peptidylarginine deiminase (PADI) 2 catalyzes the post-translational conversion of peptidyl-arginine to peptidyl-citrulline in a process called citrullination. However, the precise functions of ...
Oct 15, 2020 · Peptidylarginine deiminases (PADs) are a family of calcium-dependent enzymes that are involved in a variety of human disorders, including cancer and autoimmune diseases. Although targeting PAD4 has shown no benefit in sepsis, the role of PAD2 remains unknown. Here, we report that PAD2 is engaged in sepsis and sepsis-induced acute lung injury in ...
