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1. en.wikipedia.org › wiki › PER3PER3 - Wikipedia

   en.wikipedia.org › wiki › PER3

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   The PER3 gene encodes the period circadian protein homolog 3 protein in humans. PER3 is a paralog to the PER1 and PER2 genes. It is a circadian gene associated with delayed sleep phase syndrome in humans.

2. www.nature.com › articles › s41598/019/42390-9Role of Per3, a circadian clock gene, in embryonic ... - Nature

   www.nature.com › articles › s41598/019/42390-9

   Apr 10, 2019 · Per3 is one of the primary components of circadian clock system. While circadian dysregulation is known to be involved in the pathogenesis of several neuropsychiatric diseases. It remains...

   • Author: Mariko Noda, Ikuko Iwamoto, Hidenori Tabata, Takanori Yamagata, Hidenori Ito, Koh-ichi Nagata

   • Publish Year: 2019

3. People also ask

   Is PER3 associated with diurnal preference 23?

   • Despite the limited role of PER3 in the central clock mechanism, multiple SNPs and VNTRs in PER3 have been linked to diurnal preference 23, or chronotype, the circadian phenotype that describes an individual’s peak state of arousal and preference for activity at particular times of day 11, 24 – 27.

   Circadian Clock Model Supports Molecular Link Between PER3 and Hum…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC5579000/

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   Does PER3 affect the circadian cycle?

   • This suggests that the effect of PER3 in the regulation of the circadian cycle potentially alters additional downstream physiological processes that are critical for mood regulation. PER3 is known to be involved in modulation of alerting effects of light and the influence of light on sleep 52, 53.

   Circadian Clock Model Supports Molecular Link Between PER3 and Hum…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC5579000/

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   Does PER3 affect light sensitivity?

   • Nevertheless, the data indicate a significant contribution of PER3 to sleep and circadian phenotypes and diseases, which may be connected by common pathways. Thus, PER3-dependent altered light sensitivity could relate to high retinal PER3 expression and may contribute to altered brain response to light, diurnal preference and seasonal mood.

   Phenotyping of PER3 variants reveals widespread effects on circadian

   pubmed.ncbi.nlm.nih.gov/29248294/

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   Is PER3 a structural polymorphism?

   • The PER3 “length” polymorphism in the 54-bp repeat sequence in exon 18 (GenBank accession no. AB047686) is a structural polymorphism due to an insertion or deletion of 18 amino acids in a region encoding a putative phosphorylation domain. The polymorphism has been associated with diurnal preference and delayed sleep phase syndrome.

   PER3 - Wikipedia

   en.wikipedia.org/wiki/PER3

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4. www.ncbi.nlm.nih.gov › pmc › articlesCircadian Clock Model Supports Molecular Link Between PER3 ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Aug 31, 2017 · The inclusion of PER3 interactions into our comprehensive circadian clock model enables us to predict circadian phenotypes (e.g., altered period length) associated with mood disorders and to identify critical effects of PER3 mutations on CKIδ/ε and CRY binding.

   • Author: Amanda R. Liberman, Soo Bin Kwon, Ha T. Vu, Allan Filipowicz, Ahmet Ay, Krista K. Ingram
   • DOI: 10.1038/s41598-017-07957-4

   • Publish Year: 2017
   • Publication: Sci Rep. 2017; 7: 9893.

5. www.ncbi.nlm.nih.gov › pmc › articlesSleep Quality, Sleep Structure, and PER3 Genotype Mediate ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Aug 26, 2020 · The PER3 VNTR genotype significantly predicts depressive symptoms in a model with objective sleep parameters, but it does not significantly predict depressive symptoms in a model with chronotype or subjective sleep disturbance. Interestingly, PER3 5,5 genotypes, in males only, are independently related to chronotype and depression scores. Our ...

   • Author: Chloe Weiss, Kerri Woods, Allan Filipowicz, Krista K Ingram
   • DOI: 10.3389/fpsyg.2020.02028

   • Publish Year: 2020
   • Publication: Front Psychol. 2020; 11: 2028.

6. www.ncbi.nlm.nih.gov › genePER3 period circadian regulator 3 [ Homo sapiens (human) ]

   www.ncbi.nlm.nih.gov › gene

   Apr 3, 2024 · Title: PER3 plays anticancer roles in the oncogenesis and progression of breast cancer via regulating MEK/ERK signaling pathway. A circadian rhythm gene (PER3) VNTR variant as possible risk factor in cohort of Turkish females with primary dysmenorrhea.

7. www.sciencedirect.com › per3PER3 - an overview | ScienceDirect Topics

   www.sciencedirect.com › per3

   PER3 is a circadian clock gene that regulates sleep homeostasis and diurnal preference. Learn about the variable number of tandem repeats in exon 18 of PER3 and how it affects sleep deprivation, performance, and brain activation in humans and mice.

8. pubmed.ncbi.nlm.nih.gov › 29248294Phenotyping of PER3 variants reveals widespread effects on ...

   pubmed.ncbi.nlm.nih.gov › 29248294

   Period3 (Per3) is one of the most robustly rhythmic genes in humans and animals. It plays a significant role in temporal organisation in peripheral tissues. The effects of PER3 variants on many phenotypes have been investigated in targeted and genome-wide studies.