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Mar 31, 2020 · PMID: 31969440. PMCID: PMC7108832. DOI: 10.1128/JVI.01957-19. Abstract. The features of herpes simplex virus 1 (HSV-1) strain 129 (H129), including natural neurotropism and anterograde transneuronal trafficking, make it a potential tool for anterograde neural circuitry tracing.
Dec 10, 2022 · The H129 Amp tracer system is a powerful tracing tool for revealing neuronal connectomes. Similar content being viewed by others. Single-cell long-read sequencing-based mapping reveals...
May 12, 2017 · The H129-ΔTK-tdT anterograde monosynaptic tracing system offers a useful tool for mapping the direct output in neuronal circuitry. H129-G4 is an anterograde multisynaptic tracer with a labeling signal strong enough to display the details of neuron morphology.
Mar 31, 2020 · Anterograde transneuronal tracers derived from herpes simplex virus 1 (HSV-1) strain 129 (H129) are important tools for mapping neural circuit anatomic and functional connections. It is, therefore, critical to elucidate the transport pattern of H129 within neurons and between neurons.
Abstract. Anterograde viral tracers are powerful and essential tools for dissecting the output targets of a brain region of interest. They have been developed from herpes simplex virus 1 (HSV-1) strain H129 (H129), and have been successfully applied to map diverse neural circuits.
Dec 10, 2022 · The H129 Amp tracer system is a powerful tracing tool for revealing neuronal connectomes. Subject terms: Neural circuits, Biological techniques. Minimizing toxicity of herpes simplex virus 1 (HSV) based tools for anterograde tracing is important for functional studies.
Jan 10, 2022 · Therefore, we created a novel H129-derived anterograde monosynaptic tracer (H129-dgK) by targeting gK, which overcomes the limitations of H129-dTK. Using our established platform and pipeline for developing viral tracers, we generated a novel tracer by deleting the gK gene from the H129-G4.
