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1. www.ncbi.nlm.nih.gov › pmc › articlesUnderstanding APE1 cellular functions by the structural...

   www.ncbi.nlm.nih.gov › pmc › articles

   Jun 24, 2021 · Mammalian apurinic/apyrimidinic (AP) endonuclease 1 (APE1) has versatile enzymatic functions, including redox, endonuclease, and exonuclease activities. APE1 is thus broadly associated with pathways in DNA repair, cancer cell growth, and drug resistance.

   • Author: Tung-Chang Liu, Kai-Wei Guo, Jhih-Wei Chu, Yu-Yuan Hsiao
   • DOI: 10.1016/j.csbj.2021.06.036

   • Publish Year: 2021
   • Published: 2021

2. www.nature.com › articles › s41467/022/33057-7Structural basis for APE1 processing DNA damage in the ...

   www.nature.com › articles › s41467/022/33057-7

   Sep 14, 2022 · Here, we determine how the base excision repair (BER) endonuclease AP-endonuclease 1 (APE1) recognizes and cleaves DNA damage in the nucleosome. Kinetic assays determine that APE1 cleaves...

3. www.nature.com › articles › s41467/020/20853-2APE1 distinguishes DNA substrates in exonucleolytic ... - Nature

   www.nature.com › articles › s41467/020/20853-2

   Jan 27, 2021 · Nature Communications - The exonuclease Apurinic/apyrimidinic endonuclease 1 (APE1) is important for processing matched/mismatched terminus during DNA repair. Here the authors resolve...

   • Author: Tung Chang Liu, Chun Ting Lin, Kai Cheng Chang, Kai Wei Guo, Shuying Wang, Jhih Wei Chu, Yu Yuan Hsi...

   • Publish Year: 2021

4. www.nature.com › articles › s41598/019/56981-zArchitecture of The Human Ape1 Interactome Defines Novel ...

   www.nature.com › articles › s41598/019/56981-z

   Jan 8, 2020 · APE1 is essential in cancer cells due to its central role in the Base Excision Repair pathway of DNA lesions and in the transcriptional regulation of genes involved in tumor...

   • Author: Dilara Ayyildiz, Giulia Antoniali, Chiara D'Ambrosio, Giovanna Mangiapane, Emiliano Dalla, Andrea Sc...

   • Publish Year: 2020

5. www.ncbi.nlm.nih.gov › pmc › articlesMolecular Mechanisms Regulating the DNA Repair Protein APE1 ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Jun 11, 2021 · Abstract. APE1 (DNA (apurinic/apyrimidinic site) endonuclease 1) is a key enzyme of one of the major DNA repair routes, the BER (base excision repair) pathway. APE1 fulfils additional functions, acting as a redox regulator of transcription factors and taking part in RNA metabolism. The mechanisms regulating APE1 are still being deciphered.

   • Author: David J. López, José A. Rodríguez, Sonia Bañuelos
   • DOI: 10.3390/ijms22126308

   • Publish Year: 2021
   • Publication: Int J Mol Sci. 2021 Jun; 22(12): 6308.

6. www.ncbi.nlm.nih.gov › pmc › articlesAPE1/Ref-1 Role in Inflammation and Immune Response - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 28, 2022 · APE1 is the major apurinic/apyrimidinic endonuclease in the base excision repair pathway and acts as a redox-dependent regulator of several transcription factors, including NF-κB, AP-1, HIF-1α, and STAT3. These functions render APE1 vital to regulating cell signaling, senescence, and inflammatory pathways.

7. People also ask

   What does APE1 stand for?

   • Marenstein D.R., Wilson III D.M., Teebor G.W. Human AP endonuclease (APE1) demonstrates endonucleolytic activity against AP sites in single-stranded DNA. DNA Repair (Amst). 2004;3(5):527–533. [ PubMed] [ Google Scholar] 53.

   Understanding APE1 cellular functions by the structural preference of

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8258793/

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   What is APE1 cleavage?

   • APE1 is thus broadly associated with pathways in DNA repair, cancer cell growth, and drug resistance. Unlike its AP site-specific endonuclease activity in Base excision repair (BER), the 3′-5′ exonucleolytic cleavage of APE1 using the same active site exhibits complex substrate selection patterns, which are key to the biological functions.

   Understanding APE1 cellular functions by the structural preference of

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8258793/

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   Why is APE1 important?

   • The biological importance of APE1, and the processing of genomic AP sites, is highlighted by the embryonic lethality of APE1 knockout in M. musculus 10, and the sensitivity of APE1-deficient cells to DNA damaging agents 11, 12.

   Structural basis for APE1 processing DNA damage in the ... - Nature

   www.nature.com/articles/s41467-022-33057-7

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   Why is APE1 important in cancer cells?

   • Scientific Reports 10, Article number: 28 ( 2020 ) Cite this article APE1 is essential in cancer cells due to its central role in the Base Excision Repair pathway of DNA lesions and in the transcriptional regulation of genes involved in tumor progression/chemoresistance.

   Architecture of The Human Ape1 Interactome Defines Novel Cancers

   www.nature.com/articles/s41598-019-56981-z

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8. www.neb.com › en › productsAPE 1 | NEB

   www.neb.com › en › products

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   APE 1 is a human enzyme that cleaves DNA at apurinic/apyrimidinic sites and has various other activities. It can also modulate the binding of some transcription factors to DNA by a redox mechanism.