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Jun 1, 2020 · Assessment of S100 protein structure, function, and expression. • Mechanism of action of S100 proteins in disease pathophysiology. • S100 proteins as biomarkers for disease detection and prognosis. • Therapeutic strategies targeting S100 proteins to treat disease.
Jun 18, 2021 · In this review, we outline the potential role of the S100 protein members in pulmonary diseases and detail potential molecular mechanisms they may play in disease initiation and progression. Equally, we outline potential therapeutic approaches to treat pulmonary diseases by targeting S100 proteins. 2.
Jan 1, 2020 · The S100 family proteins possess a variety of intracellular and extracellular functions. They interact with multiple receptors and signal transducers to regulate pathways that govern inflammation, cell differentiation, proliferation, energy metabolism, apoptosis, calcium homeostasis, cell cytoskeleton and microbial resistance.
Jan 4, 2018 · Extracellular S100 proteins may regulate the apoptosis, proliferation, differentiation, and migration of a number of cell types including monocytes, macrophages, neutrophils, lymphocytes, myoblast, epithelial cells, endothelial cells, smooth muscle cells, neurons, and fibroblasts.
Here we detail S100 target protein interactions that underpin the mechanistic basis to their function, and discuss potential intervention strategies targeting S100 proteins in both preclinical and clinical situations.
S100 protein family consists the largest subgroup of the Ca 2+- binding EF-hand (helix E-loop-helix F) protein group. These proteins are called S100 because of their solubility in a 100%-saturated solution with ammonium sulphate at neutral pH. They were first identified by B.W. Moore in 1965 1.
May 1, 2002 · S100 proteins regulate intracellular processes such as cell growth and motility, cell cycle regulation, transcription and differentiation. Twenty members have been identified so far, and altogether, S100 proteins represent the largest subgroup in the EF-hand Ca2+ -binding protein family.
