Oct 28, 2010 · Furthermore, the F1174L mutation inhibits crizotinib mediated downregulation of ALK signaling and blocks apoptosis in RANBP2-ALK Ba/F3 cells. A ...
Apr 28, 2011 · Two hot spots of ALK mutations have been observed at positions F1174 and R1275. Here, we studied stably transfected cell lines expressing wild- ...
Mar 19, 2021 · F1174 mutations were more commonly associated with MYCN amplification compared with other ALK mutations (46% v 22%, respectively; P = .02).
Jan 17, 2011 · Our results show that constitutive activation of ALK results in its impaired maturation and intracellular retention. Furthermore, they provide a ...
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Apr 3, 2023 · ... F1174 mutation. Single-agent lorlatinib demonstrated clinical ... F1174 and R1245. Certain key characteristics, such as MYCN status ...
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... F1174 and R1275 mutation hotspots, respectively, were resequenced with an extremely high depth of coverage. Results: At the F1174 hotspot (exon 23) ...
Gene Variant Detail ; gDNA, chr2:g.29220829_29220831 ; cDNA, c.3520_3522 ; Protein, p.F1174 ; Source Database, RefSeq ; Genome Build, GRCh38/hg38 ...