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Apr 5, 2024 · Nikolaj Frost, Razi Ghori, Ananya Roy, Ana Tablante Nunes, James Chih-Hsin Yang; Abstract CT283: Phase 3 MK-2870-007 study: MK-2870 (SKB264) plus pembrolizumab vs pembrolizumab alone as first-line treatment for metastatic non-small-cell lung cancer with PD-L1 tumor proportion score (TPS) ≥50%. Cancer Res 1 April 2024; 84 (7_Supplement): CT283.
Aug 15, 2020 · Abstract. Background: Biliary tract cancer (BTC), including intra- or extrahepatic cholangiocarcinoma (CCA) and gallbladder cancer, is an aggressive malignancy with limited treatment options. Most patients (pts) present with advanced or unresectable disease, for which the current first-line standard of care is gemcitabine with cisplatin. Prognosis for these pts is poor, with median survival of ...
The randomized, placebo-controlled, double-blind, phase 3 KEYNOTE-966 trial will be conducted to evaluate pembrolizumab in combination with gemcitabine and cisplatin in patients with metastatic or unresectable locally advanced biliary tract carcinoma. Background: Biliary tract cancer (BTC), including intra- or extrahepatic cholangiocarcinoma (CCA) and gallbladder cancer, is an aggressive ...
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Aug 15, 2020 · Request PDF | Abstract CT283: KEYNOTE-966: A randomized, double-blind, placebo-controlled, phase 3 study of pembrolizumab in combination with gemcitabine and cisplatin for the treatment of ...
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Apr 5, 2024 · Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr CT283. In patients with relapsed or refractory locally advanced or metastatic NSCLC, MK-2870 monotherapy showed encouraging antitumor activity with a manageable safety profile, and the complementary mechanisms of action of MK-2870 and pembrolizumab may provide more potent ...
