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Jul 7, 2020 · Notably, these “S6 mutations” in Cav3.1 and Cav3.2 are reminiscent to several de novo gain-of-function mutations recently described in other genes encoding Cav channels (Fig. (Fig.3). 3). These other Cav “S6 mutations” also cause severe, mainly neurodevelopmental, clinical phenotypes.
- Philippe Lory, Sophie Nicole, Arnaud Monteil
- 10.1007/s00424-020-02429-7
- 2020
- Pflugers Arch. 2020; 472(7): 831-844.
Cav3.1 is a T type calcium channel, also know as a1G. It is a low voltage activated (LVA) calcium channel found in neurons and cardiac tissue. Calcium channels are multimeric proteins consisting of a pore forming alpha-1 subunit and some combination of auxiliary beta, alpha-2delta and gamma subunits [477].
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Apr 15, 2019 · T-Type Cav3.1 Channels Mediate Progression and Chemotherapeutic Resistance in Glioblastoma | Cancer Research | American Association for Cancer Research. Molecular Cell Biology | April 15 2019. T-Type Ca v 3.1 Channels Mediate Progression and Chemotherapeutic Resistance in Glioblastoma. Anna Visa; Marta C. Sallán; Oscar Maiques; Lía Alza;
Oct 15, 2018 · PMCID: PMC6197829. PMID: 30410396. CAV3.1 knockdown suppresses cell proliferation, migration and invasion of prostate cancer cells by inhibiting AKT. Shanbiao Hu, 1 Ling Li, 2 Wei Huang, 3 Jie Liu, 4 Gongbin Lan, 1 Shaojie Yu, 1 Longkai Peng, 1 Xubiao Xie, 1 Luoyan Yang, 2 Yeqi Nian, 2 and Yinhuai Wang 2.
- Shanbiao Hu, Ling Li, Wei Huang, Jie Liu, Gongbin Lan, Shaojie Yu, Longkai Peng, Xubiao Xie, Luoyan ...
- 10.2147/CMAR.S172948
- 2018
- Cancer Manag Res. 2018; 10: 4603-4614.
Nov 15, 2023 · Ca v 1.2 channels play crucial roles in various neuronal and physiological processes. Here, we present cryo-EM structures of human Ca v 1.2, both in its apo form and in complex with several drugs, as well as the peptide neurotoxin calciseptine.
Apr 19, 2022 · Structural bases of inhibitory mechanism of CaV1.2 channel inhibitors. Article. Structural basis for human Cav3.2 inhibition by selective antagonists. Article. Cryo-EM structures of apo and...
May 17, 2023 · Importantly, Ca V 1.2–Ca V β 3 interactions with the TM dock and Cyto dock involve highly conserved channel subunit elements (Extended Data Fig. 3c,f), suggesting that Ca V s comprising...
