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m-RNA binding protein involved in regulation of mitotic nuclear division, meitotic cell cycle and protein O-linked mannosylation; part of the ribonucleoprotein complex; localizes to endoplasmic reticulum and cytoplasm.
Dec 10, 2019 · Bfr1 regulates Pmt1 and Pmt2 translation and therefore impacts on UPOM. Bfr1 is a cytoplasmic protein without any common RNA interacting motifs that was described as a component of polyribosome associated mRNP complexes in S. cerevisiae .
- Joan Castells-Ballester, Natalie Rinis, Ilgin Kotan, Lihi Gal, Daniela Bausewein, Ilia Kats, Ewa Zat...
- 2019
Jun 1, 1994 · We used a multicopy genomic DNA library to search for multicopy suppressors of BFA-induced lethality. We identified one such gene, BFR1, that, in addition, partially suppresses the growth and secretion defects of the ER-to-Golgi secretion mutant sec17.
- C L Jackson, F Képès
- 1994
Jun 15, 2001 · INTRODUCTION. Bfr1p is a 55 kDa protein of unknown function in Saccharomyces cerevisiae. The gene, BFR1, was cloned in 1994 from a genetic screen for high-copy suppressors of brefeldin-A (BFA) induced lethality ( 1 ).
- Brian D. Lang, Ai-min Li, Heather D. Black-Brewster, Judith L. Fridovich-Keil
- 2001
Polysome profiling of bfr1Δ or bfr1 mutant strains reveals a strong shift of ERG4 mRNA to polysomes, consistent with a function of Bfr1p in elongation or increased ribosome loading. Collectively, our data reveal that Bfr1 has at least two separable functions: one in RNA binding and cotranslational protein translocation into the ER and one in ...
- Srinivas Manchalu, Nitish Mittal, Anne Spang, Ralf-Peter Jansen
- 2019
Brefeldin A resistance factor 1 (Bfr1p) is a nonessential RNA-binding protein and multicopy suppressor of brefeldin A sensitivity in Saccharomyces cerevisiae. Deletion of BFR1 leads to multiple defects, including altered cell shape and size, change in ploidy, induction of P-bodies and chromosomal missegregation.
BFR1. Status. UniProtKB reviewed (Swiss-Prot) Organism. Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) Amino acids. 470 (go to sequence) Protein existence. Evidence at protein level.
